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BBR 2778, a novel anthracenedione, induces DNA intercalation and inhibition of the topoisomerase-II enzyme. In this study BBR 2778 was given as a 1 h intravenous infusion weekly for 3 weeks (w) every 4 w.

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2007 Jun;25(3):187-95. [4]. Ubiali F, et al. Pixantrone (BBR2778) reduces the severity of experimental autoimmune myasthenia gravis in Lewis rats. BBR 2778 (6,9 [bis (2-aminoethyl)-amino]-benzo [g] isoquinolone-5,10-dione dimaleate salt) is a novel heteroanalogue of anthracenediones ().The mechanism of action of BBR 2778 is similar to that of mitoxantrone in terms of DNA intercalation, DNA affinity, topoisomerase II interaction and formation of single strand breaks. BBR 2778 is a novel aza-anthracenedione showing no cardiotoxicity and superior activity compared to doxorubicin and mitoxantrone in animal models.

Bbr 2778

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10. VÄVAREN *3. 2562 Boverkets byggregler (föreskrifter och allmänna råd), BBR 19. 27.

2002-03-15 · BBR 2778 and BBR 2378 were synthesized at Boehringer Mannheim Italia. DEH was synthesized by David E. Horn, Goucher College. Purity of all the compounds was assured using NMR and TLC. The photoaffinity probe NHS-ASA was purchased from Pierce. The procedure used to synthesize photolabeled DEH and BBR 2778 is described in our recent report .

BBR 2778. Pixantrone. BSA. Dec 12, 2018 (2003) Phase-II study of the new aza- anthracenedione, BBR 2778, in patients with relapsed aggressive non-Hodgkin's lymphomas.

Bbr 2778

Jan 19, 2010 7, Pixantrone (BBR 2778), Cell Therapeutics, Filed, 48, 449. 8, Xiaflex, Auxilium Pharmaceuticals + Pfizer, Filed, 53, 386. 9, Movectro, Merck 

Bbr 2778

26432 KLIPPAN. 2779 JOSEF. CZERNY BBR EKONOMI AB LEGERINGSGATAN 5. 72130 VÄSTERÅS.

Bbr 2778

This study eval … These results indicate that 85 mg/m2 BBR 2778 in a q1w x 3 schedule is active in elderly and pretreated patients with relapsed aggressive NHL and was generally well tolerated. Thus, we recommend further clinical evaluation of this new compound in phase-III studies for the treatment of NHL. BBR 2778 plasma pharmacokinetics were biphasic (mean t(1/2) at 180 mg/m2 = 14.1 h) and the urinary elimination of the unchanged drug was < 10%. In a patient with previously treated small cell lung carcinoma (SCLC), a 49% reduction in measurable disease was noted with resolution of pericardial and pleural effusions (120 mg/m2 x eight cycles). Cavalletti E, et al. Pixantrone (BBR 2778) has reduced cardiotoxic potential in mice pretreated with doxorubicin: comparative studies against doxorubicin and mitoxantrone.
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Pixantrone (BBR2778) reduces the severity of experimental autoimmune myasthenia gravis in Lewis rats. Original article Phase I study of BBR 2778, a new aza-anthracenedione, in advanced or refractory non-Hodgkin’s lymphoma P. Borchmann, 1 R. Schnell, 1 R. Knippertz, 1 J.O. Staak, 1 G.M. Camboni, 2 A. Bernareggi, 2 K. Hübel, 1 P. Staib, 1 A. Schulz, 1 V. Diehl, 1 A. Engert, 1 [email protected] de 1 Klinik I für Innere Medizin der Universität Köln, Köln, Germany Klinik I BBR 2778 (6,9 [bis (2-aminoethyl)-amino]-benzo [g] isoquinolone-5,10-dione dimaleate salt) is a novel heteroanalogue of anthracenediones ().The mechanism of action of BBR 2778 is similar to that of mitoxantrone in terms of DNA intercalation, DNA affinity, topoisomerase II interaction and formation of single strand breaks. BBR 2778. A substance that is being studied in the treatment of cancer.
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Bbr 2778





Also known as · Code name: BBR 2778 · Generic name: pixantrone dimaleate · Brand name: Pixuvri.

Ivan Ridberg, skattmastar Pine Street, tel. SUtter 8171. Logen Odin, No. 1.0.0  Våtvagn, trådkorg, svabb, sopborste etc Hygiente ,6 2778,4 694,6 2778,4 Stolvåg på smålägenheter enligt BBR 3:21 och enligt remissutgåva 06 10 27 Studie  BBR Automotive, 001-10-00137. BOSCH, CS091, (denna /8 (W114) | 1968.01-1976.11 250 2.8 (114.011) - 2778ccm, 130pk, 96kw - M 130.923. /8 (W114)  läsas i BBR 2008 kap 8;353.